Isaac Bissell, [Thomas², John¹]was born 22 September 1682 in Windsor, Hartford County, Connecticut. He was the son of Thomas Bissell and Abigail Moore. He married Elizabeth Osborn 02 May 1706.

Isaac and Elizabeth’s children were born in Windsor. Isaac Bissell was confirmed Lieutenant in the North Company of the Trainband of Windsor in October 1722. These military bands or companies were created in England by James I and served as the town militia.

Isaac removed from Windsor to Litchfield, Connecticut when he purchased approximately 700 acres there in 1723. Isaac also owned property on North Street in Litchfield that was known as the "old red house" which was demolished circa 1857.

Isaac died 6 November 1744 at Litchfield and is buried in the West Burial Ground.